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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2A
All Species:
4.85
Human Site:
S1449
Identified Species:
7.62
UniProt:
P11388
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.43
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11388
NP_001058.2
1531
174385
S1449
K
R
D
P
A
L
N
S
G
V
S
Q
K
P
D
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
P1496
L
K
Q
T
D
K
V
P
S
K
T
V
A
A
K
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
P1482
L
K
Q
I
D
K
V
P
S
K
T
V
A
A
K
Dog
Lupus familis
XP_537646
1532
174610
S1450
K
K
D
P
G
L
N
S
D
V
S
Q
K
P
D
Cat
Felis silvestris
Mouse
Mus musculus
Q01320
1528
172859
A1445
K
S
D
S
A
L
S
A
R
V
S
E
K
P
A
Rat
Rattus norvegicus
P41516
1526
173202
A1445
K
S
D
S
A
L
N
A
H
V
S
K
K
P
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519680
1746
195650
K1479
T
R
A
K
D
K
G
K
Y
Q
S
R
S
R
T
Chicken
Gallus gallus
O42130
1553
174974
K1471
E
A
T
A
A
V
A
K
K
P
G
P
P
R
G
Frog
Xenopus laevis
NP_001082502
1579
178601
K1464
Q
K
P
K
N
E
D
K
Q
P
S
I
L
D
A
Zebra Danio
Brachydanio rerio
NP_001003834
1574
177254
K1458
S
I
L
D
V
L
S
K
A
S
P
K
K
S
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
K1365
P
G
R
R
Q
A
S
K
K
I
D
Y
S
S
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
K1434
E
K
K
P
S
T
S
K
K
P
S
P
K
K
A
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
P1366
G
K
K
G
A
K
K
P
K
R
N
P
W
S
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
S1383
E
V
L
A
I
G
V
S
P
E
K
K
V
R
K
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
Q1347
K
K
P
V
R
K
Q
Q
K
V
V
E
L
S
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.2
67.5
93.6
N.A.
89
88.7
N.A.
71.3
76.3
70.7
67.9
N.A.
51.2
N.A.
53
58.9
Protein Similarity:
100
78.6
78.4
96.4
N.A.
93.6
93.2
N.A.
79.1
85
81.8
78.8
N.A.
66.8
N.A.
70.4
73.4
P-Site Identity:
100
0
0
80
N.A.
53.3
60
N.A.
13.3
6.6
6.6
13.3
N.A.
0
N.A.
20
13.3
P-Site Similarity:
100
13.3
13.3
86.6
N.A.
73.3
73.3
N.A.
20
20
26.6
26.6
N.A.
13.3
N.A.
46.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
45
42.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.4
60.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
14
34
7
7
14
7
0
0
0
14
14
27
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
27
7
20
0
7
0
7
0
7
0
0
7
20
% D
% Glu:
20
0
0
0
0
7
0
0
0
7
0
14
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
7
7
0
7
7
7
7
0
7
0
7
0
0
0
14
% G
% His:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% H
% Ile:
0
7
0
7
7
0
0
0
0
7
0
7
0
0
0
% I
% Lys:
34
47
14
14
0
34
7
40
34
14
7
20
40
7
27
% K
% Leu:
14
0
14
0
0
34
0
0
0
0
0
0
14
0
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
7
0
20
0
0
0
7
0
0
0
0
% N
% Pro:
7
0
14
20
0
0
0
20
7
20
7
20
7
27
0
% P
% Gln:
7
0
14
0
7
0
7
7
7
7
0
14
0
0
0
% Q
% Arg:
0
14
7
7
7
0
0
0
7
7
0
7
0
20
0
% R
% Ser:
7
14
0
14
7
0
27
20
14
7
47
0
14
27
0
% S
% Thr:
7
0
7
7
0
7
0
0
0
0
14
0
0
0
7
% T
% Val:
0
7
0
7
7
7
20
0
0
34
7
14
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
7
0
0
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _